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Mammalian Genetics
The
Mammalian Genetics Research Group, headed by Professor Alan
Clarke, uses embryonic stem cell-based transgenic technologies to
study mammalian gene function, with a particular focus on the analysis
of gene dysregulation during development and disease.
The
principal interests of the Mammalian Genetics group are:
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the in vivo role of a range of tumour suppressor
genes in determining the predisposition to cell death, response
to DNA damage, mutation burden, genomic stability and predisposition
to neoplasia. Genes currently under study include Apc, p53,
Msh-2, Mlh-1, Pms-2 and Pten
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the in vivo role of genes which contain methyl
binding domains
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the in vivo role of molecules within the
Jak-Stat signal transduction cascade, with particular relevance
to the genetic control of apoptosis
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the development of new methodologies to enhance
transgenesis
Principal
Researchers:
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Professor
Alan R Clarke
Professorial
Fellow
Cardiff
School of Biosciences, Cardiff University |
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Professor
Sir Martin Evans
Professor
of Mammalian Genetics
Director of Cardiff School of Biosciences, Cardiff University |
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